Evidence that amikacin ototoxicity is related to total perilymph area under the concentration-time curve regardless of concentration
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چکیده
منابع مشابه
Limited sampling model for area under the concentration time curve of total topotecan.
Antitumor activity of topotecan, a new derivative of camptothecin, has been documented in many tumors. The active lactone form of topotecan is in equilibrium with the inactive hydroxyacid form. However, dose-limiting toxicity, neutropenia, is correlated to the area under the concentration time curve (AUC) of not only the lactone form but also total (lactone + hydroxyacid) topotecan. Because the...
متن کاملAssociation between vancomycin trough concentration and area under the concentration-time curve in neonates.
National treatment guidelines for invasive methicillin-resistant Staphylococcus aureus (MRSA) infections recommend targeting a vancomycin 24-h area under the concentration-time curve (AUC0-24)-to-MIC ratio of >400. The range of vancomycin trough concentrations that best predicts an AUC0-24 of >400 in neonates is not known. This understanding would help clarify target trough concentrations in ne...
متن کاملLimited Sampling Strategies to Estimate the Area under the Concentration-time Curve
H. Tsuruta1; M. Fukumoto2; L. Bax3; A. Kohno4; Y. Morishita4 1Department of Medical Informatics, School of Allied Health Sciences, Kitasato University, Kanagawa, Japan; 2Division of Toxicology, Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan; 3Pharsight Corporation, Sunnyvale, CA, USA; 4Department of Hematology and Oncolog...
متن کاملTwo formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change.
Study protocols in endocrinological research and the neurosciences often employ repeated measurements over time to record changes in physiological or endocrinological variables. While it is desirable to acquire repeated measurements for finding individual and group differences with regard to response time and duration, the amount of data gathered often represents a problem for the statistical a...
متن کاملLimited sampling strategies to estimate the area under the concentration-time curve. Biases and a proposed more accurate method.
BACKGROUND Over 100 limited sampling strategies (LSSs) have been proposed to reduce the number of blood samples necessary to estimate the area under the concentration-time curve (AUC). The conditions under which these strategies succeed or fail remain to be clarified. OBJECTIVES We investigated the accuracy of existing LSSs both theoretically and numerically by Monte Carlo simulation. We also...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1991
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.35.6.1070